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KMID : 0357920030370050369
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Korean Journal of Pathology
2003 Volume.37 No. 5 p.369 ~ p.372
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Silica Granuloma after Intermittent Intramuscular Injections - A Case Report -
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Choi Suk-Jin
Lee Jong-Im
Kim Jung-Ran
Jang Suk-Yong
Kim Ki-Kwon
Chung Phil-Hyun
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Abstract
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Most silica-contaminated wounds of the skin heal without complications. Cutaneous silica granuloma is a poorly understood, uncommon condition resembling a sarcoidosis. We report a case of silica granuloma after intermittent intramuscular injections. A 70-year-old man presented a painless mass in his right buttock for 2 weeks. He had received intermittent intramuscular injections of antihistamine drugs due to chronic dermatitis for 30 years. The histolopathological findings showed numerous hyalinized collagenous nodules with concentric layers, and an ill-defined chronic granulomatous inflammation containing foreign material. A polarized light microscopic examination revealed birefrigent particles. The presence of silica components was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis.
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KEYWORD
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Silicon dioxide, Granuloma, Injection, intramuscular
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